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In end-stage disease, epithelial changes may no longer be visible, and gross distortion of the vulva may be the only remaining sign

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The relationship of smoking among boys and that of their social circle is particularly problematic for boys in the context of gender identity formation given the current high prevalence of smoking among boys and adult men in Indonesia and the representation of masculinised characteristics in association with smoking in tobacco industry advertising 7,8

For the different formulations, the nicotine content was based on the molecular weight of the free base to ensure that equal amounts of nicotine were present